Therapeutic benefit of melatonin in refractory central serous chorioretinopathy

GRAMAJO, ANA; MARQUEZ, GABRIEL; TORRES, VICTOR EDUARDO; JUAREZ, CLAUDIO

EYE

NATURE PUBLISHING GROUP

Lugar: Londres; Año: 2015 vol. 29 p. 1003 - 1003

0950-222X

URPOSE:To evaluate the efficacy and safety of melatonin for the treatment of chronic central serous chorioretinopathy (CSCR).METHODS:Prospective comparative case series. A total of 13 patients with chronic CSCR were treated for 1 month: 8 patients were treated orally with 3 mg melatonin t.i.d., and 5 with placebo. All patients had 20/40 or worse Early Treatment Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity (BCVA) in the affected eye or presented an incapacitating scotoma. Most of the patients had previous failed treatments for their condition. Observational procedures included ETDRS BCVA, and complete ophthalmic examination. Optical coherence tomography (OCT) was performed at day 1 and week 4. Fluorescein angiography was performed at baseline only for diagnostic purposes. Data were subjected to two-sample t-test statistical analysis. P-values of <0.05 were considered statistically significant.RESULTS:At 1-month